Contents
1:00 PM Introduction and Welcome, Prof. Fred Maxfield, Dept. of Biochemistry, Weill Cornell Medical College 1:10 PM Scientific Introduction, Chair, David Eliezer, WMCCU 1:20 PM Reed Wickner, NIH/NIDDK, "Yeast Prion Structure Explains Yeast Prion Biology" 2:20 PM Angus Nairn, Yale University, "Intrinsically unstructured proteins play a critical role in neuronal signal transduction" 3:20 PM Coffee Break 3:40 PM Carol Prives, Columbia University, "P53 and Mdm2: interplay between structure and function" Speaker Biosketches: Reed Wickner, M.D. is currently Chief of the Laboratory of Biochemistry and Genetics at the National Institute of Diabetes & Digestive & Kidney Diseases, part of the National Institutes of Health. His research interests pertain to prions and amyloid diseases. His studies of infectious elements of S. cerevisiae have led to the discovery of prions, dsRNA viruses, and naked ssRNA replicons, their similarities with similar elements in animal cells and some clues of the mechanisms by which they are propagated and interact with their host. He is a member of the National Academy of Sciences.
http://www2.niddk.nih.gov/NIDDKLabs/IntramuralFaculty/WicknerReed.htm ; Publications Angus Nairn, Ph.D is professor of Psychiatry at Yale University. His research focuses on the molecular actions of dopamine in the basal ganglia and the disruption of normal dopaminergic neurotransmission which is known to underlie certain neurological diseases, including Huntington's and Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder.
http://www.med.yale.edu/psych/faculty/nairn.html ; Publications Carol Prives, Ph.D. is the DaCosta professor in the Department of Biological Sciences at Columbia University. Her work includes understanding the structure and function of the normal p53 protein and how it differs from the mutant p53 proteins that are commonly found in cancer patients' tumors. Another ongoing project in her laboratory is the elucidation of the mechanisms by which Mdm2 and MdmX keep p53 in check. She is a member of the National Academy of Sciences.
http://www.columbia.edu/cu/biology/faculty-data/carol-prives/faculty.html ; Publications
Future of Structural Biology - 2009
New Series in Challenges in Biology
Program -- Challenges in Biology - 1:00PM Wednesday Mar 18, 2009 - Rockefeller University, Weiss Building, 17th floor
A series of nomadic / peripatetic lectures in New York by distinguished lecturers.Intrinsically Disordered Proteins in Health and Disease
1:00 PM Introduction and Welcome, Prof. Fred Maxfield, Dept. of Biochemistry, Weill Cornell Medical College 1:10 PM Scientific Introduction, Chair, David Eliezer, WMCCU 1:20 PM Reed Wickner, NIH/NIDDK, "Yeast Prion Structure Explains Yeast Prion Biology" 2:20 PM Angus Nairn, Yale University, "Intrinsically unstructured proteins play a critical role in neuronal signal transduction" 3:20 PM Coffee Break 3:40 PM Carol Prives, Columbia University, "P53 and Mdm2: interplay between structure and function" Speaker Biosketches: Reed Wickner, M.D. is currently Chief of the Laboratory of Biochemistry and Genetics at the National Institute of Diabetes & Digestive & Kidney Diseases, part of the National Institutes of Health. His research interests pertain to prions and amyloid diseases. His studies of infectious elements of S. cerevisiae have led to the discovery of prions, dsRNA viruses, and naked ssRNA replicons, their similarities with similar elements in animal cells and some clues of the mechanisms by which they are propagated and interact with their host. He is a member of the National Academy of Sciences.
http://www2.niddk.nih.gov/NIDDKLabs/IntramuralFaculty/WicknerReed.htm ; Publications Angus Nairn, Ph.D is professor of Psychiatry at Yale University. His research focuses on the molecular actions of dopamine in the basal ganglia and the disruption of normal dopaminergic neurotransmission which is known to underlie certain neurological diseases, including Huntington's and Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder.
http://www.med.yale.edu/psych/faculty/nairn.html ; Publications Carol Prives, Ph.D. is the DaCosta professor in the Department of Biological Sciences at Columbia University. Her work includes understanding the structure and function of the normal p53 protein and how it differs from the mutant p53 proteins that are commonly found in cancer patients' tumors. Another ongoing project in her laboratory is the elucidation of the mechanisms by which Mdm2 and MdmX keep p53 in check. She is a member of the National Academy of Sciences.
http://www.columbia.edu/cu/biology/faculty-data/carol-prives/faculty.html ; Publications
Organized by Prof. David Eliezer, and sponsored by Weill Cornell Medical College and the New York Structural Biology Center
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